反应详情

To a solution of 4-methyl-2-nitro-phenylamine (202 mg, 1.33 mmol) and benzaldehyde (0.68 mL, 6.65 mmol) in 5 mL dry dichloromethane at room temperature, was added sodium triacetoxyborohydride (282 mg, 1.33 mmol). Then acetic acid (76 μl, 1.33 mmol) was added. The reaction mixture was stirred at room temperature for 1 h. The solvent was evaporated and the solid was dissolved in ethyl acetate. The organic layer was washed with saturated NaHCO3, dried over MgSO4, filtered, and the solvent was removed in vacuo. The crude material was purified by flash chromatography to yield 300 mg (1.24 mmol, 94%) of benzyl-(4-methyl-2-nitro-phenyl)-amine.

1. customThe solvent was evaporated
2. dissolutionthe solid was dissolved in ethyl acetate
3. washThe organic layer was washed with saturated NaHCO3
4. dry with materialdried over MgSO4
5. filtrationfiltered
6. customthe solvent was removed in vacuo
7. customThe crude material was purified by flash chromatography