Cyclohexanecarboxaldehyde → HCID 178477507, compound

HRID 1822545Notes

Reaction equation

HRID 1822545 reaction equation
O=CC1CCCCC1.CCSC(=O)C(F)C(=O)O>C1CCNCC1.CN(C)c1ccncc1.C1CCOC1>CCSC(=O)/C(F)=C/C1CCCCC1

Participants

6

Reactant 2

HCID 16275CyclohexanecarboxaldehydeHCID 178477510HCID 178477510, compound

Product 1

HCID 178477507HCID 178477507, compoundYield 90%

Reagents, catalysts & solvents 3

HCID 142844-(Dimethylamino)pyridineReagentHCID 8082PiperidineCatalystHCID 8028TetrahydrofuranSolvent

Conditions

Temperature
50 °C

Workup

  1. temperatureThe product mixture was cooled to 25 °C.
  2. filtrationFiltered through a pad of celite · Keep Organic
  3. wash"The celite was washed with ethyl acetate (3 x 1 mL)."
  4. concentrationThe filtrate was concentrated under reduced pressure
  5. additionA 0.07 M stock solution of the internal standard ethylene carbonate (0.70 mL in CDCl3) was added.

Sources & evidence

ORD record
ord-8e1c35aa97814d0a9be5be430de2da78
Source dataset
Bayesian optimization of 5 decarboxylative olefination reactions

Reaction notes

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