反应详情

To a solution of benzamide (1.42 g) in tetrahydrofuran (50 ml) were added sodium hydride (611 mg) and 4-bromobenzenesulfonyl chloride (3.0 g), and the mixture was stirred at room temperature for 3 hours. The mixture was diluted with ethyl acetate and water. The organic layer was separated, washed with brine, dried over magnesium sulfate and evaporated. The residue was purified by column chromatography on silica gel (hexane/ethyl acetate=2/1) to give N-benzoyl-4-bromobenzenesulfonamide (2.1 g) as a colorless powder.

1. customThe organic layer was separated
2. washwashed with brine
3. dry with materialdried over magnesium sulfate
4. customevaporated
5. customThe residue was purified by column chromatography on silica gel (hexane/ethyl acetate=2/1)