Sodium Bicarbonate → HCID 22141272, compound

HRID 1826511Notes

Reaction equation

HRID 1826511 reaction equation
O.O[N:3]1C2C=CC=CC=2N=N1.Cl.CN(C)CCCN=C=NCC.[CH3:24][C:25]1[N:30]=[C:29](/[CH:31]=[CH:32]/[C:33]([OH:35])=O)[CH:28]=[CH:27][CH:26]=1.[CH3:36][C:37]1([C:43]2[CH:44]=[C:45]([NH:49][S:50]([CH3:53])(=[O:52])=[O:51])[CH:46]=[CH:47][CH:48]=2)[CH:42]2[CH:38]1[CH2:39][NH:40][CH2:41]2.C(=O)([O-])O.[Na+]>CN(C)C=O.ClCCl.O>[NH3:3].[CH3:36][C:37]1([C:43]2[CH:44]=[C:45]([NH:49][S:50]([CH3:53])(=[O:52])=[O:51])[CH:46]=[CH:47][CH:48]=2)[CH:42]2[CH:38]1[CH2:39][N:40]([C:33](=[O:35])/[CH:32]=[CH:31]/[C:29]1[CH:28]=[CH:27][CH:26]=[C:25]([CH3:24])[N:30]=1)[CH2:41]2

Participants

10

Reactant 5

HCID 516892Sodium BicarbonateHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 27960291-Hydroxybenzotriazole hydrateHCID 21671572HCID 21671572, compoundHCID 22141143N-[3-(6-methyl-3-azabicyclo[3.1.0]hex-6-yl)phenyl)methanesulfonamide

Product 2

HCID 222AmmoniaHCID 22141272HCID 22141272, compoundYield 70.3%

Reagents, catalysts & solvents 3

HCID 962WaterSolventHCID 6228DimethylformamideSolventHCID 6344DichloromethaneSolvent

Procedure

A solution of 1-hydroxybenzotriazole monohydrate (112 mg, 0.73 mmol) and 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (153 mg, 0.80 mmol) in N,N-dimethylformamide (5 ml) was added to (E)-3-(6-methyl-2-pyridinyl)-2-propenoic acid (F. Freeman, L. Y. Chang, J. C. Kappos and L. Sumarta, J. Org. Chem., 1987, 52, 1460; 108 mg, 0.66 mmol). After stirring at room temperature for 15 min, the mixture was added to the hydrochloride salt of N-[3-(6-methyl-3-azabicyclo[3.1.0]hex-6-yl)phenyl]methanesulfonamide (Preparation 53, 202 mg, 0.66 mmol) and sodium hydrogen carbonate (110 mg, 1.32 mmol). The reaction mixture was stirred at room temperature for overnight and then water (10 ml) and dichloromethane (5 ml) were added. The biphasic mixture was separated by filtering through a Whatman Microfiltration Device Filter Tube, and the resulting organic extract was concentrated using a stream of nitrogen to afford 290 mg of a crude cream solid. This was purified by chromatography using a Biotage Flash 40S™ cartridge packed with silica gel (40 g) eluting with dichloromethane:ethanol:0.880 ammonia (100:2:1) to afford the title compound as a white solid (191 mg, 70%).

Workup

  1. stirringThe reaction mixture was stirred at room temperature for overnight
  2. customThe biphasic mixture was separated
  3. filtrationby filtering through a Whatman Microfiltration Device
  4. filtrationFilter Tube
  5. extractionthe resulting organic extract
  6. concentrationwas concentrated
  7. customto afford 290 mg of a crude cream solid
  8. customThis was purified by chromatography
  9. washeluting with dichloromethane

Sources & evidence

ORD record
ord-e351eae5f6e74fd890fb583a0a46bb1d
Source dataset
uspto-grants-2006_05
Patent number
US07049444B2

Reaction notes

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