Sodium hydride → HCID 54717658, compound

HRID 1828640Notes

Reaction equation

HRID 1828640 reaction equation
C([O:5][C:6](=O)[C:7]1[CH:12]=[C:11]([O:13][CH2:14][O:15][CH3:16])[CH:10]=[CH:9][C:8]=1[S:17][CH2:18][C:19]([O:21][CH2:22][CH2:23][CH2:24][CH3:25])=[O:20])CCC.[H-].[Na+]>CN(C=O)C>[CH2:22]([O:21][C:19]([C:18]1[S:17][C:8]2[CH:9]=[CH:10][C:11]([O:13][CH2:14][O:15][CH3:16])=[CH:12][C:7]=2[C:6]=1[OH:5])=[O:20])[CH2:23][CH2:24][CH3:25]

Participants

4

Reactant 2

HCID 24758Sodium hydrideHCID 21028585HCID 21028585, compound

Product 1

HCID 54717658HCID 54717658, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

6.20 g (16 mmol) IV and 0.80 g (20 mmol, 60%) NaH were stirred for 5 h at room temperature in 80 ml DMF. The solvent was removed and the residue was taken up in 250 ml CHCl3, washed three times with water and dried over Na2SO4. Recrystallization from n-hexane gave 4.22 g (13.6 mmol, 85%) V.

Workup

  1. customThe solvent was removed
  2. washwashed three times with water
  3. dry with materialdried over Na2SO4
  4. customRecrystallization from n-hexane
  5. customgave 4.22 g (13.6 mmol, 85%) V

Sources & evidence

ORD record
ord-bb80a1a9f9294af5aace5dfcc254feb0
Source dataset
uspto-grants-2006_06
Patent number
US07060109B2

Reaction notes

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