Diethylamine → HCID 22059719, compound

HRID 1828899Notes

Reaction equation

HRID 1828899 reaction equation
[CH2:1]([NH:3][CH2:4][CH3:5])[CH3:2].Cl[CH2:7][C:8]([C:10]1[C:11]([CH3:18])=[C:12]([CH:16]=[O:17])[NH:13][C:14]=1[CH3:15])=[O:9]>C1COCC1>[CH3:18][C:11]1[C:10]([C:8](=[O:9])[CH2:7][N:3]([CH2:4][CH3:5])[CH2:1][CH3:2])=[C:14]([CH3:15])[NH:13][C:12]=1[CH:16]=[O:17]

Participants

4

Reactant 2

HCID 8021DiethylamineHCID 220598554-(Chloroacetyl)-3,5-dimethyl-1H-pyrrole-2-carbaldehyde

Product 1

HCID 22059719HCID 22059719, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Diethylamine (5 ml) was added to a solution of 4-(2-Chloroacetyl)-3,5-dimethylpyrrole-2-carboxaldehyde (1 g, 5 mmol) in THF (20 ml). The mixture was stirred at room temperature for 24 h. The solvent was removed under reduced pressure and the residue was treated with water, NaHCO3 (5%) and extracted with dichloromethane. After drying and filtering, the solvent was removed and the residue was used without further purification.

Workup

  1. customThe solvent was removed under reduced pressure
  2. additionthe residue was treated with water, NaHCO3 (5%)
  3. extractionextracted with dichloromethane
  4. customAfter drying
  5. filtrationfiltering
  6. customthe solvent was removed
  7. customthe residue was used without further purification

Sources & evidence

ORD record
ord-f5763b2445974eb093d9337134f23510
Source dataset
uspto-grants-2006_06
Patent number
US07060822B1

Reaction notes

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