反应详情

温度

60 °C

(R)-2-(Benzyloxycarbonylamino)-1,4-dimethanesulfonyloxybutane (2.0 g; 5.06 mmol) was dissolved in a Et3N/DMSO mixture (1:1, 20 ml). Hydroxylamine hydrochloride (1.4 g; 20.2 mmol) was added and the mixture was heated at 60° C. over night. The mixture was poured in aqueous HCl (the pH was adjusted to pH=6 with NaHCO3) and extracted twice with AcOEt. The organic phase was washed with water and dried over Na2SO4. The solids were filtered off and the solvent was removed. A light yellow oil (1.4 g, purity 73%) was obtained (yield: 85%). The crude title compound was used as is.

1. extractionextracted twice with AcOEt
2. washThe organic phase was washed with water
3. dry with materialdried over Na2SO4
4. filtrationThe solids were filtered off
5. customthe solvent was removed
6. customA light yellow oil (1.4 g, purity 73%) was obtained (yield: 85%)