Nitrogen → HCID 86600483, compound

HRID 1829930Notes

Reaction equation

BrCC1C=CN2C=1C(Cl)=NC=N2.N#N.S1C=CC=C1CC(O)=O.CCN(C(C)C)C(C)C.Cl[C:34]1[C:39]2=[C:40]([CH2:43][S:44][C:45](=[O:47])[CH3:46])[CH:41]=[CH:42][N:38]2[N:37]=[CH:36][N:35]=1.[Cl:48][C:49]1[CH:50]=[C:51]([NH2:64])[CH:52]=[CH:53][C:54]=1[O:55][CH2:56][C:57]1[CH:62]=[CH:61][CH:60]=[C:59]([F:63])[CH:58]=1>C(Cl)Cl.ClCCCl.C(O)CCC>[Cl:48][C:49]1[CH:50]=[C:51]([NH:64][C:34]2[C:39]3=[C:40]([CH2:43][S:44][C:45](=[O:47])[CH3:46])[CH:41]=[CH:42][N:38]3[N:37]=[CH:36][N:35]=2)[CH:52]=[CH:53][C:54]=1[O:55][CH2:56][C:57]1[CH:62]=[CH:61][CH:60]=[C:59]([F:63])[CH:58]=1

Participants

Conditions

Temperature: 85 °C

Procedure

A solution of 5-bromomethyl-4-chloro-pyrrolo[2,1-f][1,2,4]triazine (1 gm, 4.05 mmole) in DCM (40 mL) was sparged with N2 for 15 min. The solution was cooled in an ice bath and thiolacetic acid (0.319 mL, 1.1 equiv) and DIPEA (0.71 mL, 1 equiv) were added. After 0.5 h, the reaction was removed from the bath and after an additional 0.5 h, it was washed with water (3×), dried (Na2SO4), and the solvent was removed. The crude thioacetic acid S-(4-chloro-pyrrolo[2,1-f][1,2,4]triazin-5-ylmethyl) ester and 3-chloro-4-(3-fluoro-benzyloxy)-phenylamine (0.915 mg, 0.9 equiv) were dissolved in a mixture of 1,2-dichloroethane (4 mL) and n-butanol (4 mL) and heated at 85° C. for 1 h. The solvents were removed and the residue was partitioned between DCM and sat. aq. NaHCO3 solution. The organic phase was separated, washed with water, dried (Na2SO4), and the solvent removed. Radial chromatography (silica gel plate eluted with DCM containing 0, 0.5, 1% MeOH) afforded thioacetic acid S-{4-[3-chloro-4-(3-fluoro-benzyloxy)-phenylamino]-pyrrolo[2,1-f][1,2,4]triazin-5-ylmethyl} ester (986 mg, 54%). A portion of this thioester (120 mg, 0.263 mmole) was dissolved in dry THF and sparged with N2 for 15 min. NaOMe (0.525 mL of a 0.5 M solution of NaOMe in MeOH, 1.1 equiv) and MeI (0.016 mL) were added with stirring. After 0.5 h, the solvents were removed and the residue was partitioned between DCM and water. The organic phase was separated, dried (Na2SO4), and the solvent was removed. Purification by radial chromatography (silica gel plate eluted with DCM containing 0, 0.5, 1% MeOH) afforded [3-chloro-4-(3-fluoro-benzyloxy)-phenyl]-(5-methylsulfanyl-methyl-pyrrolo[2,1-f][1,2,4]triazin-4-yl)-amine (91 mg, 81%): 1H NMR (CDCl3) δ 2.26 (s, 3H), 4.06 (s, 2H), 5.19 (s, 2H), 6.57 (d, 1H, J=2.6 Hz), 6.95–7.93 (m, 10H), 8.86 (s, 1H). Solid m-chloroperbenzoic acid (54 mg, 58 to 70%, 1 equiv) was added to an ice-cooled solution of the thioether (91 mg, 0.21 mmole) in CHCl3. After 1 h, this was removed from the bath and washed with a 6% aq. solution of NaHSO3 and sat. aq. NaHCO3 (3×) and then dried (Na2SO4). Radial chromatography (silica gel plate eluted with DCM containing 0, 0.5, 1, 2, 3% MeOH) afforded the title compound (49 mg, 51%): MS: 445 (M+H)+; HPLC Ret Time: 1.70 min (YMC Xterra C18 S7, 3.0×50 mm column, 2 min gradient, 5 mL/min).

Workup

temperatureThe solution was cooled in an ice bath
customthe reaction was removed from the bath and after an additional 0.5 h
washit was washed with water (3×)
dry with materialdried (Na2SO4)
customthe solvent was removed
customThe solvents were removed
customthe residue was partitioned between DCM and sat. aq. NaHCO3 solution
customThe organic phase was separated
washwashed with water
dry with materialdried (Na2SO4)
customthe solvent removed
washRadial chromatography (silica gel plate eluted with DCM containing 0, 0.5, 1% MeOH)

Sources & evidence

ORD record: ord-b9dc0ca8b2f14d3aa6e7c0d42cdb0c86
Source dataset: uspto-grants-2006_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07064203B2

Reaction notes

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