HRID1830482

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID13878454

4-Ethynyl-1,2-difluorobenzene

C8H4F2

HCID22044694

未命名化合物

PRODUCTS

生成物

结构：CCCc1ccc2c(ccc3cc(C#Cc4ccc(F)c(F)c4)ccc32)c1

HCID22045090

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

结构：c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1

催化剂HCID178418397

未命名化合物

溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

溶剂HCID8471

Triethylamine

C6H15N

PROCEDURE

实验过程

2-iodo-7-propyl-phenanthrene in dimethylformamide and triethylamine was reacted with 4-ethynyl-1,2-difluorobenzene in the presence of tetrakis(triphenylphosphine)palladium (0), and the product was purified by silica gel column chromatography (hexane) and then recrystallized from ethanol to yield 2-propyl-7-(3,4-difluorophenylethynyl)phenanthrene.

WORKUP

后处理

customthe product was purified by silica gel column chromatography (hexane)
customrecrystallized from ethanol

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-ac944e5887e14e1e8f8962fe1013c3f8
来源数据集: uspto-grants-2006_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07067179B1
来源说明: uspto-grants-2006_06

反应 SMILES

I[C:2]1[CH:15]=[CH:14][C:13]2[C:12]3[C:7](=[CH:8][C:9]([CH2:16][CH2:17][CH3:18])=[CH:10][CH:11]=3)[CH:6]=[CH:5][C:4]=2[CH:3]=1.[C:19]([C:21]1[CH:26]=[CH:25][C:24]([F:27])=[C:23]([F:28])[CH:22]=1)#[CH:20]>CN(C)C=O.C(N(CC)CC)C.C1C=CC([P]([Pd]([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1>[CH2:16]([C:9]1[CH:10]=[CH:11][C:12]2[C:13]3[C:4](=[CH:3][C:2]([C:20]#[C:19][C:21]4[CH:26]=[CH:25][C:24]([F:27])=[C:23]([F:28])[CH:22]=4)=[CH:15][CH:14]=3)[CH:5]=[CH:6][C:7]=2[CH:8]=1)[CH2:17][CH3:18]