HCID 22048468, compound → HCID 22048480, compound

HRID 1830815Notes

Reaction equation

HRID 1830815 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:8]2[C:17]3[C:12](=[CH:13][CH:14]=[C:15]([C:18]([C:26]4[N:30]([CH3:31])[CH:29]=[N:28][CH:27]=4)([C:20]4[N:24]([CH3:25])[CH:23]=[N:22][CH:21]=4)[OH:19])[CH:16]=3)[N:11]=[C:10]([O:32]C)[CH:9]=2)[CH:5]=[CH:6][CH:7]=1>Cl.C1COCC1>[ClH:1].[Cl:1][C:2]1[CH:3]=[C:4]([C:8]2[C:17]3[C:12](=[CH:13][CH:14]=[C:15]([C:18]([OH:19])([C:20]4[N:24]([CH3:25])[CH:23]=[N:22][CH:21]=4)[C:26]4[N:30]([CH3:31])[CH:29]=[N:28][CH:27]=4)[CH:16]=3)[NH:11][C:10](=[O:32])[CH:9]=2)[CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 1

HCID 22048468HCID 22048468, compound

Product 1

HCID 22048480HCID 22048480, compoundYield 214.7%

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 8028TetrahydrofuranSolvent

Procedure

A mixture of intermediate (7) (0.00141 mol) in HCl 3N (20 ml) and THF (5 ml) was stirred and refluxed overnight. The solvent was evaporated till dryness. The product was used without further purification, yielding 0.73 g (quant.) of 4-(3-chlorophenyl)-6-[hydroxybis(1-methyl-1H-imidazol-5-yl)methyl]-2(1H)-quinolinone hydrochloride (1:2).

Workup

  1. temperaturerefluxed overnight
  2. customThe solvent was evaporated till dryness
  3. customThe product was used without further purification

Sources & evidence

ORD record
ord-2f5b3a5ec95740d391d40c2fcd10d924
Source dataset
uspto-grants-2006_06
Patent number
US07067531B2

Reaction notes

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