Triethylamine → HCID 17393823, compound

HRID 1831004Notes

Reaction equation

HRID 1831004 reaction equation
Cl.CN.[C:4]([C:6]1[CH:7]=[C:8]([S:12](Cl)(=[O:14])=[O:13])[CH:9]=[CH:10][CH:11]=1)#[N:5].[CH2:16]([N:18](CC)CC)[CH3:17]>O1CCCC1.O.C(OCC)(=O)C>[C:4]([C:6]1[CH:7]=[C:8]([S:12]([NH:18][CH2:16][CH3:17])(=[O:14])=[O:13])[CH:9]=[CH:10][CH:11]=1)#[N:5]

Participants

7

Reactant 3

HCID 8471TriethylamineHCID 28013603-Cyanobenzene-1-sulfonyl chlorideHCID 6364545Methylamine hydrochloride

Product 1

HCID 17393823HCID 17393823, compoundYield 86%

Reagents, catalysts & solvents 3

HCID 962WaterSolventHCID 8028TetrahydrofuranSolventHCID 8857Ethyl AcetateSolvent

Procedure

Methylamine hydrochloride (736 mg, 10.9 mmol) was added to a solution of 3-cyano benzene sulfonyl chloride (2.0 g, 9.9 mmol) and triethylamine (3.45 ml, 24.7 mmol) in tetrahydrofuran (30 ml) and the resulting mixture left to stir at room temperature under a nitrogen atmosphere for 16 h hours. The reaction mixture was diluted with water (30 ml) and ethyl acetate (50 ml). The organic phase was separated and dried (sodium sulfate) and reduced in vacuo to give the title compound as a colourless solid (1.68 g, 86%).

Workup

  1. waitthe resulting mixture left
  2. customThe organic phase was separated
  3. dry with materialdried (sodium sulfate)

Sources & evidence

ORD record
ord-fe74032b70c84cbe991d66898207b75f
Source dataset
uspto-grants-2006_06
Patent number
US07067541B2

Reaction notes

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