Sodium Iodide → N-(3-{1-(5-(2-fluorophenyl)-5-oxopentyl]-4-piperidinyl}phenyl)-2-methylpropanamide

HRID 1833034Notes

Reaction equation

HRID 1833034 reaction equation
C([O-])([O-])=O.[K+].[K+].[Na+].[I-].Cl[CH2:10][CH2:11][CH2:12][CH2:13][C:14]([C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=1[F:22])=[O:15].[CH3:23][CH:24]([CH3:40])[C:25]([NH:27][C:28]1[CH:33]=[CH:32][CH:31]=[C:30]([CH:34]2[CH2:39][CH2:38][NH:37][CH2:36][CH2:35]2)[CH:29]=1)=[O:26]>>[F:22][C:17]1[CH:18]=[CH:19][CH:20]=[CH:21][C:16]=1[C:14](=[O:15])[CH2:13][CH2:12][CH2:11][CH2:10][N:37]1[CH2:38][CH2:39][CH:34]([C:30]2[CH:29]=[C:28]([NH:27][C:25](=[O:26])[CH:24]([CH3:23])[CH3:40])[CH:33]=[CH:32][CH:31]=2)[CH2:35][CH2:36]1

Participants

5

Reactant 4

HCID 5238Sodium IodideHCID 11430Potassium CarbonateHCID 167572552-methyl-N-[3-(4-piperidyl)phenyl]propanamideHCID 220488005-Chloro-1-(2-fluorophenyl)-1-oxopentane

Product 1

HCID 22049199N-(3-{1-(5-(2-fluorophenyl)-5-oxopentyl]-4-piperidinyl}phenyl)-2-methylpropanamide

Procedure

Prepared by Procedure K and Scheme E using K2CO3 instead of Na2CO3 and NaI instead of KI and 5-chloro-1-(2-fluorophenyl)-1-pentanone and 2-methyl-N-[3-(4-piperidinyl)phenyl]propanamide: ESMS m/e: 425.2 (M+H)+.

Workup

  1. customPrepared by Procedure K and Scheme E

Sources & evidence

ORD record
ord-4f03461454b84e4b9f0d4375182a03b5
Source dataset
uspto-grants-2006_06
Patent number
US07067534B1

Reaction notes

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