Diisopropyl Ether → HCID 12526286, compound

HRID 1833818Notes

Reaction equation

HRID 1833818 reaction equation
C(N(CC)CC)C.[CH3:8][N:9]=[C:10]=[O:11].[OH:12][C:13]1[N:17]=[C:16]([S:18][CH2:19][C:20]2[CH:25]=[CH:24][C:23]([Cl:26])=[CH:22][CH:21]=2)[S:15][N:14]=1.C(OC(C)C)(C)C>O1CCCC1>[CH3:8][NH:9][C:10]([N:14]1[C:13](=[O:12])[N:17]=[C:16]([S:18][CH2:19][C:20]2[CH:25]=[CH:24][C:23]([Cl:26])=[CH:22][CH:21]=2)[S:15]1)=[O:11]

Participants

6

Reactant 4

HCID 7914Diisopropyl EtherHCID 8471TriethylamineHCID 12228Methyl IsocyanateHCID 178519019HCID 178519019, compound

Product 1

HCID 12526286HCID 12526286, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Conditions

Temperature
20 °C

Procedure

0.2 ml of triethylamine and 6 ml of methyl isocyanate were added to a solution of 12.9 g of 3-hydroxy-5-(p-chlorobenzylthio)-1,2,4-thiadiazole in 100 ml of tetrahydrofuran and after stirring the mixture for 2 hours at 20° C, isopropyl ether was added thereto. The mixture was filtered and the crystals were empasted with isopropyl ether and dried to obtain 15 g of 2-(N-methylcarbamoyl)-5-(p-chlorobenzylthio)-1,2,4-thiadiazole-3-one melting at 140° C.

Workup

  1. filtrationThe mixture was filtered
  2. customdried

Sources & evidence

ORD record
ord-9dc88e47f47841d493a95b82bf5cfeec
Source dataset
uspto-grants-1978_01
Patent number
US04067720

Reaction notes

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