Hexane → HCID 9834198, compound

Temperature

50 °C

2-Bromo-1,3-thiazole (3.1 g, 19 mmol) and CuI (360 mg, 1.9 mmol) were combined in DME (30 mL) and argon gas was bubbled through the suspension for several minutes to deoxygenate the mixture. Triethylamine (13 mL, 94 mmol) and PdCl2(PPh3)2 (660 mg, 0.94 mmol) were added and 1-ethynycyclopentanol (2.5 g, 23 mmol) was added dropwise. The reaction was heated at 50° C. for 16 h at which time GC/MS analysis indicated that the reaction was complete. The mixture was filtered through Celite™, and the filter pad was washed thoroughly with ethyl acetate. The combined filtrates were concentrated in vacuo and the residue was dissolved in ethyl acetate (300 mL), washed with water (300 mL), brine (300 mL), dried over Na2SO4, filtered, and concentrated in vacuo. The residue was purified by column chromatography eluting with hexane, 6:1 then 3:1 hexane:ethyl acetate to afford 1-(1,3-thiazol-2-ylethynyl)cyclopentanol (2.3 g, 52% yield) as a yellow powder. 1H NMR (CDCl3, 300 MHz) δ 7.80 (d, J=3 Hz, 1H), 7.65 (d, J=3 Hz, 1H), 2.04-1.73 (m, 10.8H). MS (EI ionization) 193 (M+).

1. customargon gas was bubbled through the suspension for several minutes
2. customto deoxygenate the mixture
3. addition1-ethynycyclopentanol (2.5 g, 23 mmol) was added dropwise
4. filtrationThe mixture was filtered through Celite™
5. washthe filter pad was washed thoroughly with ethyl acetate
6. concentrationThe combined filtrates were concentrated in vacuo
7. dissolutionthe residue was dissolved in ethyl acetate (300 mL)
8. washwashed with water (300 mL), brine (300 mL)
9. dry with materialdried over Na2SO4
10. filtrationfiltered
11. concentrationconcentrated in vacuo
12. customThe residue was purified by column chromatography
13. washeluting with hexane, 6:1

ORD record

ord-d24305a804be44a4bc2d5cb43bf06cc8

Source dataset

uspto-grants-2004_08

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06774138B2