反应详情

温度

120 °C

0.853 g (6.20 mmol) of K2CO3, 0.154 g (0.90 mmol) of Kl and 1.000 g (3.10 mmol) of ethyl 2,4-dibromo-3-hydroxybenzoate were introduced into 15 ml of DMF. 0.346 g (3.70 mmol) of chloroacetamide was added at RT, and the mixture was heated for 6 hours at 120° C. The mixture was then poured into water and extracted with diisopropyl ether. The combined organic phases were washed with water, dried over Na2SO4 and concentrated completely. Drying in an oil-pump vacuum gave ethyl 2,4-dibromo-3-(aminocarbonylmethoxy)benzoate as a brown oil.

1. extractionextracted with diisopropyl ether
2. washThe combined organic phases were washed with water
3. dry with materialdried over Na2SO4
4. concentrationconcentrated completely
5. customDrying in an oil-pump vacuum