反应详情

Morphine sulfate (1.67 g, 5×10−3 mol) was dissolved with potassium carbonate (2.07 g, 1.5×10−2 mol) in 80 ml ethanol. The solution was heated to reflux while stirring and a solution containing bromoacetic acid (0.7 g, 5×10−3 mol) added in 2 ml ethanol. This was refluxed for 2 hr, then the flask was cooled in an ice-water bath. The pH was adjusted to 3 with 12 N hydrochloric acid and precipitates were filtered. Solvents were evaporated under vacuum and 10 ml ethanol was added to the residue. Precipitates were filtered and solvents evaporated under vacuum. The residue was recrystallized from water/acetone (10:90). Approximately 300 mg of the desired product was recovered.

1. temperatureThe solution was heated
2. temperatureto reflux
3. temperatureThis was refluxed for 2 hr
4. temperaturethe flask was cooled in an ice-water bath
5. customprecipitates
6. filtrationwere filtered
7. customSolvents were evaporated under vacuum and 10 ml ethanol
8. additionwas added to the residue
9. customPrecipitates
10. filtrationwere filtered
11. customsolvents evaporated under vacuum
12. customThe residue was recrystallized from water/acetone (10:90)
13. customApproximately 300 mg of the desired product was recovered