Hydrochloric Acid → HCID 23499226, compound

HRID 1836310Notes

Reaction equation

HRID 1836310 reaction equation
C(OC(=O)[NH:7][CH2:8][C:9]([CH:12]1[CH2:21][CH:20]([N:22]2[C:30](=[O:31])[C:29]3[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=3)[C:23]2=[O:32])[C:19]2[C:14](=[CH:15][CH:16]=[C:17]([N+:33]([O-:35])=[O:34])[CH:18]=2)[NH:13]1)([CH3:11])[CH3:10])(C)(C)C.Cl>O1CCCC1>[NH2:7][CH2:8][C:9]([CH:12]1[CH2:21][CH:20]([N:22]2[C:23](=[O:32])[C:24]3[C:29](=[CH:28][CH:27]=[CH:26][CH:25]=3)[C:30]2=[O:31])[C:19]2[C:14](=[CH:15][CH:16]=[C:17]([N+:33]([O-:35])=[O:34])[CH:18]=2)[NH:13]1)([CH3:11])[CH3:10]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 12049569HCID 12049569, compound

Product 1

HCID 23499226HCID 23499226, compoundYield 74.6%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The compound of Example 2 (200 mg) was dissolved in 2 ml of tetrahydrofuran, and 2 ml of 2N hydrochloric acid was added. After overnight stirring at room temperature, the reaction mixture was filtered under reduced pressure. The resulting solid was dried in a vacuum to obtain 119 mg of the title compound. Its physical properties are shown below.

Workup

  1. filtrationthe reaction mixture was filtered under reduced pressure
  2. customThe resulting solid was dried in a vacuum

Sources & evidence

ORD record
ord-7d6cdf4729c44d75b3417a676ad2fb5c
Source dataset
uspto-grants-2004_08
Patent number
US06777427B2

Reaction notes

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