反应详情

At room temperature, 5.0 g (24.87 mmol) of 4-bromo-3,5-dimethylphenol, 2.03 g (29.84 mmol) of imidazole and 6.23 g (32.33 mmol) of chloro(triisopropyl)silane are stirred in 20 ml of dimethylformamide overnight. Saturated sodium bicarbonate solution is then added, and the mixture is extracted three times with diethyl ether. The combined organic phases are washed with water and dried with sodium sulphate, and the solvent is removed under reduced pressure. This gives 7.5 g (84% of theory) of 4-bromo-3,5-dimethylphenyl triisopropylsilyl ether.

1. extractionthe mixture is extracted three times with diethyl ether
2. washThe combined organic phases are washed with water
3. dry with materialdried with sodium sulphate
4. customthe solvent is removed under reduced pressure