Hydrochloric Acid → HCID 131724553, compound

HRID 1836598Notes

Reaction equation

HRID 1836598 reaction equation
[CH:1]1[CH:10]=[CH:9][C:8]2[O:11][CH2:12][CH2:13][CH2:14][N:6]3[C:7]=2[C:2]=1[C@H:3]1[CH2:17][NH:16][CH2:15][C@H:4]1[CH2:5]3.[ClH:18].Cl.[CH:20]1C=CC2OCCCN3C=2C=1[C@H]1CNC[C@H]1C3.C=O.C(O[BH-](OC(=O)C)OC(=O)C)(=O)C.[Na+].Cl>ClCCCl.C(O)C.CCOCC.C(O)(=O)C>[ClH:18].[ClH:18].[CH3:20][N:16]1[CH2:17][C@H:3]2[C@H:4]([CH2:5][N:6]3[CH2:14][CH2:13][CH2:12][O:11][C:8]4[CH:9]=[CH:10][CH:1]=[C:2]2[C:7]3=4)[CH2:15]1

Participants

10

Reactant 5

HCID 313Hydrochloric AcidHCID 712FormaldehydeHCID 5049666Sodium triacetoxyborohydrideHCID 23518416HCID 23518416, compoundHCID 131724551HCID 131724551, compound

Product 1

HCID 131724553HCID 131724553, compound

Reagents, catalysts & solvents 4

HCID 111,2-DichloroethaneSolventHCID 176Acetic AcidSolventHCID 702EthanolSolventHCID 3283Diethyl EtherSolvent2×

Procedure

To a solution of (±)-cis-6,7,9,9a,10,11,12,12a-octahydro-5H-[1,4]oxazepino[2,3,4-ij]pyrrolo[3,4-c]quinoline trifluroracetic acid salt from EXAMPLE 121 (100 mg, 0.29 mmol) in 10 mL of 1,2-dichloroethane was added 37% aqueous formaldehyde (0.05 mL, 0.58 mmol) and sodium triacetoxyborohydride (0.19 g, 0.87 mmol) and a couple drops of acetic acid. The resulting mixture was stirred at ambient temperature for 1 h and then the reaction was quenched with water. The mixture was partitioned between chloroform and saturated aqueous sodium carbonate. The organics were washed with brine, dried (K2CO3) and concentrated in vacuo. A portion of the residue (40 mg, 0.16 mmol) was dissolved in 1 mL ethanol and 5 mL of ether and then there was added 2M HCl in ether (0.25 mL, 0.5 mmol). A solid precipitated out of solution. The solvents were decanted and the solid was triturated twice with ether and dried in vacuo to afford the title compound of EXAMPLE 122 as an off white powder. 1H NMR (dmso-D6) δ: 11.20 (broad s, 1H), 6.85-6.77 (m, 1H), 6.75-6.70 (m, 2H), 4.27 (dt, 1H), 4.00-3.80 (m, 1H), 3.77-3.60 (m, 2H), 3.50-3.25 (m, 3H), 3.20-3.05 (m, 2H), 2.97-2.90 (m, 1H), 2.88-2.62 (m, 5H), 2.07-1.95 (m, 1H), 1.92-1.80 (m, 1H). LRMS (ES)+: 245.0 (M+H)+.

Workup

  1. customthe reaction was quenched with water
  2. customThe mixture was partitioned between chloroform and saturated aqueous sodium carbonate
  3. washThe organics were washed with brine
  4. dry with materialdried (K2CO3)
  5. concentrationconcentrated in vacuo
  6. customA solid precipitated out of solution
  7. customThe solvents were decanted
  8. customthe solid was triturated twice with ether
  9. customdried in vacuo

Sources & evidence

ORD record
ord-290250db0dd9418c86757f226d3a18e9
Source dataset
uspto-grants-2004_08
Patent number
US06777406B2

Reaction notes

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