Methanesulfonic Acid → HCID 85923180, compound

HRID 1837826Notes

Reaction equation

HRID 1837826 reaction equation
[NH2:1]/[C:2](/[CH3:8])=[CH:3]\[C:4]([O:6][CH3:7])=[O:5].[CH3:9][S:10]([OH:13])(=[O:12])=[O:11].[H][H]>[Pt].CO>[CH3:9][S:10]([OH:13])(=[O:12])=[O:11].[NH2:1][CH:2]([CH3:8])[CH2:3][C:4]([O:6][CH3:7])=[O:5]

Participants

6

Reactant 3

HCID 6395Methanesulfonic AcidHCID 643918Methyl 3-aminocrotonateHCID 178418361HCID 178418361, compound

Product 1

HCID 85923180HCID 85923180, compound

Reagents, catalysts & solvents 2

HCID 23939PlatinumCatalystHCID 887MethanolSolvent

Procedure

5.0 g (43.4 mmol) of methyl 3-aminocrotonate, 70 ml of anhydrous methanol, 1.0 equivalent of methanesulfonic acid and 0.22 g of Pt/C catalyst (Heraeus K0129) were introduced into a 160 ml Parr autoclave. The hydrogenation was carried out for 2 hours at approximately 20° C. under 5-10 bar of hydrogen. The catalyst was then filtered off and the solvent was completely removed by distillation on a rotary evaporator. 6.2 g of pure methyl (RS)-3-aminobutyrate methanesulfonate were obtained as an oil.

Workup

  1. filtrationThe catalyst was then filtered off
  2. customthe solvent was completely removed by distillation on a rotary evaporator

Sources & evidence

ORD record
ord-0d1114bfd7d94048b62b7d4d339a4027
Source dataset
uspto-grants-2004_08
Patent number
US06784311B2

Reaction notes

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