Iodoethane → HCID 18753247, compound

HRID 1838134Notes

Reaction equation

HRID 1838134 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:13][CH2:12][N:11]([C:14]3[N:19]=[C:18]([CH3:20])[NH:17][C:16](=[O:21])[C:15]=3[N+:22]([O-:24])=[O:23])[CH2:10][CH2:9]2)=[CH:4][CH:3]=1.[CH2:25](I)[CH3:26].C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[CH2:25]([O:21][C:16]1[C:15]([N+:22]([O-:24])=[O:23])=[C:14]([N:11]2[CH2:10][CH2:9][N:8]([C:5]3[CH:6]=[CH:7][C:2]([F:1])=[CH:3][CH:4]=3)[CH2:13][CH2:12]2)[N:19]=[C:18]([CH3:20])[N:17]=1)[CH3:26]

Participants

5

Reactant 3

HCID 6340IodoethaneHCID 11430Potassium CarbonateHCID 135617196HCID 135617196, compound

Product 1

HCID 18753247HCID 18753247, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

In analogy to the procedure described in example 8, the 6-[4-(4-fluoro-phenyl)-piperazin-1-yl]-2-methyl-5-nitro-3H-pyrimidin-4-one (example 1) was treated with ethyliodide and potassium carbonate in N,N-dimethylformamide at room temperature to yield the 4-ethoxy-6-[4-(4-fluoro-phenyl)-piperazin-1-yl]-2-methyl-5-nitro-pyrimidine as a light yellow solid; m.p. 116-119° C.; MS: [M+H]+=362; and the 3-ethyl-6-[4-(4-fluoro-phenyl)-piperazin-1-yl]-2-methyl-5-nitro-3H-pyrimidin-4-one as yellowish solid; m.p. 126-128° C.; MS: [M+H]+=362.

Sources & evidence

ORD record
ord-845d191d6ec148eebe22b734b0803000
Source dataset
uspto-grants-2004_01
Patent number
US06673795B2

Reaction notes

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