Diisopropylethylamine → HCID 18753219, compound

HRID 1838209Notes

Reaction equation

HRID 1838209 reaction equation
Cl[C:2]1[C:3]([C:15]#[N:16])=[N:4][C:5]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[C:6]([CH3:8])[N:7]=1.[F:17][C:18]1[CH:23]=[CH:22][C:21]([CH:24]2[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]2)=[CH:20][CH:19]=1.C(N(C(C)C)C(C)C)C>CN(C)C=O>[F:17][C:18]1[CH:23]=[CH:22][C:21]([CH:24]2[CH2:25][CH2:26][N:27]([C:2]3[C:3]([C:15]#[N:16])=[N:4][C:5]([C:9]4[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=4)=[C:6]([CH3:8])[N:7]=3)[CH2:28][CH2:29]2)=[CH:20][CH:19]=1

Participants

5

Reactant 3

HCID 81531DiisopropylethylamineHCID 27591364-(4-Fluorophenyl)piperidineHCID 18753299HCID 18753299, compound

Product 1

HCID 18753219HCID 18753219, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

In analogy to the procedure described in example 75c, the 3-chloro-5-methyl-6-phenyl-pyrazine-2-carbonitrile was treated with 4-(4-fluoro-phenyl)-piperidine and N-ethyldiisopropylamine in N,N-dimethylformamide at room temperature to yield the 3-[4-(4-fluoro-phenyl)-piperidin-1-yl]-5-methyl-6-phenyl-pyrazine-2-carbonitrile as yellow oil; MS: 373 (M+H)+.

Sources & evidence

ORD record
ord-cf3c2a37d0894f199a77e9cef21c60a1
Source dataset
uspto-grants-2004_01
Patent number
US06673795B2

Reaction notes

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