Potassium Carbonate → HCID 18753202, compound

HRID 1838211Notes

Reaction equation

HRID 1838211 reaction equation
Br[C:2]1[C:3]([C:12]#[N:13])=[N:4][CH:5]=[C:6]([NH:8][CH2:9][CH2:10][OH:11])[N:7]=1.[F:14][C:15]1[CH:20]=[CH:19][C:18]([N:21]2[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]2)=[CH:17][CH:16]=1.C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[F:14][C:15]1[CH:16]=[CH:17][C:18]([N:21]2[CH2:26][CH2:25][N:24]([C:2]3[C:3]([C:12]#[N:13])=[N:4][CH:5]=[C:6]([NH:8][CH2:9][CH2:10][OH:11])[N:7]=3)[CH2:23][CH2:22]2)=[CH:19][CH:20]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 752601-(4-Fluorophenyl)piperazineHCID 187532053-Bromo-5-[(2-hydroxyethyl)amino]-2-pyrazinecarbonitrile

Product 1

HCID 18753202HCID 18753202, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

In analogy to the procedure described in example 82c, 3-bromo-5-(2-hydroxy-ethyl-amino)-pyrazine-2-carbonitrile was treated with 1-(4-fluorophenyl)piperazine in the presence of potassium carbonate in N,N-dimethylformamide between room temperature and 80° C. to yield 4-(4-fluoro-phenyl)-6′-(2-hydroxy-ethylamino)-3,4,5,6-tetrahydro-2H-[1,2′]bipyrazinyl-3′-carbonitrile as light yellow solid; m.p. 149-151° C.; MS: 343 (M+H)+.

Sources & evidence

ORD record
ord-011749e3ed4845afa45e61a07118a42b
Source dataset
uspto-grants-2004_01
Patent number
US06673795B2

Reaction notes

Loading…