反应详情

A 1.2 M solution of lithium hydroxide (300 μL, 0.36 mmol) was added to a solution of [4-(4-benzyloxycarbonylmethoxy-3,5-diiodo-benzoyl)-2,6-diiodo-phenoxy]-acetic acid benzyl ester (prepared according to Example 12, 76 mg, 0.075 mmol) in 2.4 mL THF. The suspension was stirred for 48 hours, after which time the mixture was poured into 1 M HCl. The resulting white precipitate was isolated by filtration, rinsed with water, and dried in vacuo, yielding the title compound as a white powder (52 mg, 83%). 1H NMR (400 MHz, DMSO-d6): δ 13.17 (br. s, 2H), 8.09 (s, 4H), 4.55 (s, 4H). HPLC (40-90), 10.29 min. LRMS (EI−) calc'd for [C17H10I4O7—H] 832.7, found 832.6.

1. customThe resulting white precipitate was isolated by filtration
2. washrinsed with water
3. customdried in vacuo