Hydrochloric Acid → HCID 23447493, compound

HRID 1840586Notes

Reaction equation

HRID 1840586 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([CH2:14][C:15]2([OH:27])[CH2:20][CH2:19][N:18]([C:21]3[CH:26]=[CH:25][N:24]=[CH:23][N:22]=3)[CH2:17][CH2:16]2)[C:10](=[O:28])[CH2:9]1)=O)(C)(C)C.[ClH:29]>O1CCCC1.C(OCC)(=O)C>[ClH:29].[OH:27][C:15]1([CH2:14][N:11]2[CH2:12][CH2:13][NH:8][CH2:9][C:10]2=[O:28])[CH2:16][CH2:17][N:18]([C:21]2[CH:26]=[CH:25][N:24]=[CH:23][N:22]=2)[CH2:19][CH2:20]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 23447342HCID 23447342, compound

Product 1

HCID 23447493HCID 23447493, compound

Reagents, catalysts & solvents 2

HCID 8028TetrahydrofuranSolventHCID 8857Ethyl AcetateSolvent

Procedure

To a solution of 4-(tert-butoxycarbonyl)-1-[4-hydroxy-1-(4-pyrimidinyl)piperidin-4-ylmethyl]piperazin-2-one (516 mg) in tetrahydrofuran (4 ml) was added a solution of 4N hydrochloric acid in ethyl acetate (4 ml), and the mixture was stirred at room temperature for 4 hours. The reaction solution was concentrated, and the residue was crystallized from tetrahydrofuran to give colorless crystals of 1-[4-hydroxy-1-(4-pyrimidinyl)piperidin-4-ylmethyl]piperazin-2-one hydrochloride (435 mg).

Workup

  1. concentrationThe reaction solution was concentrated
  2. customthe residue was crystallized from tetrahydrofuran

Sources & evidence

ORD record
ord-619b29a0a35f4da9a6271338413199bc
Source dataset
uspto-grants-2004_01
Patent number
US06680312B2

Reaction notes

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