Trifluoroacetic acid → HCID 56941373, compound

HRID 1842047Notes

Reaction equation

HRID 1842047 reaction equation
FC(F)(F)C(O)=O.[CH2:8]([N:15]1[CH2:20][CH2:19][O:18][CH:17]([C:21]([NH:23][C:24]2[CH:25]=[C:26]3[C:30](=[CH:31][CH:32]=2)[N:29](C(C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[N:28]=[C:27]3[C:52]2[CH:57]=[CH:56][N:55]=[CH:54][CH:53]=2)=[O:22])[CH2:16]1)[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.C([SiH](CC)CC)C>>[CH2:8]([N:15]1[CH2:20][CH2:19][O:18][CH:17]([C:21]([NH:23][C:24]2[CH:25]=[C:26]3[C:30](=[CH:31][CH:32]=2)[NH:29][N:28]=[C:27]3[C:52]2[CH:53]=[CH:54][N:55]=[CH:56][CH:57]=2)=[O:22])[CH2:16]1)[C:9]1[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=1

Participants

4

Reactant 3

HCID 6422Trifluoroacetic acidHCID 12052TriethylsilaneHCID 66613463HCID 66613463, compound

Product 1

HCID 56941373HCID 56941373, compound

Procedure

Trifluoroacetic acid (1 mL) was added to 4-benzyl-N-(3-(pyridin-4-yl)-1-trityl-1H-indazol-5-yl)morpholine-2-carboxamide (0.0217 g, 0.0332 mmol). The reaction was stirred at room temperature for 30 minutes. Triethylsilane (0.1 mL) was added to the reaction and stirred for an additional 5 minutes. The reaction was concentrated in vacuo and purified using prep LC/MS. LC-MS: 414.26 [M+H]. LC/MS RT=1.99 min.

Workup

  1. stirringstirred for an additional 5 minutes
  2. concentrationThe reaction was concentrated in vacuo
  3. custompurified

Sources & evidence

ORD record
ord-052b375eecd940049139e0119843f9a5
Source dataset
uspto-grants-2015_02
Patent number
US08946216B2

Reaction notes

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