Hydrochloric Acid → HCID 45043168, compound

HRID 1842054Notes

Reaction equation

HRID 1842054 reaction equation
O1CCCC1.[OH:6][CH:7]1[CH2:12][CH2:11][N:10]([C:13]([O:15][C:16]([CH3:19])([CH3:18])[CH3:17])=[O:14])[CH2:9][CH:8]1[C:20]([O:22]C)=[O:21].[OH-].[Li+].Cl>O>[C:16]([O:15][C:13]([N:10]1[CH2:11][CH2:12][CH:7]([OH:6])[CH:8]([C:20]([OH:22])=[O:21])[CH2:9]1)=[O:14])([CH3:19])([CH3:17])[CH3:18]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 8028TetrahydrofuranHCID 185348061-Tert-butyl 3-methyl 4-hydroxypiperidine-1,3-dicarboxylate

Product 1

HCID 45043168HCID 45043168, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

In a flask, tetrahydrofuran (1.01 mL) was added to 1-tert-butyl 3-methyl 4-hydroxypiperidine-1,3-dicarboxylate (0.079 g, 0.303 mmol). A solution of lithium hydroxide (0.0254 g, 0.607 mmol) in water (0.505 mL) was added to the reaction. The reaction was allowed to stir at room temperature for 4 hrs. Using 1N hydrochloric acid, the reaction was neutralized to pH 6 and was concentrated in vacuo. The crude product was purified using prep LC/MS. LC-MS: 190.1 [M−t-butyl]. LC/MS RT=2.58 min.

Workup

  1. concentrationwas concentrated in vacuo
  2. customThe crude product was purified

Sources & evidence

ORD record
ord-caf3eeffd57b4fa9bf75b178400aaca9
Source dataset
uspto-grants-2015_02
Patent number
US08946216B2

Reaction notes

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