反应详情

温度

50 °C

To a solution of tri sodium chloride salt of iodo-2-(4-methylphenyl)-1,3-oxazole-5-carboxylic acid (55.2 mg, 0.11 mmol) in DMF (1.1 mL) were added (1R)-1-[1-oxido-6-(trifluoromethyl)pyridin-3-yl]ethanamine (27.9 mg, 0.12 mmol), EDC (36.7 mg, 0.19 mmol), HOAT (7.45 mg, 55.0 μmol) and triethylamine (61 μL, 0.44 mmol). The mixture was stirred at 50° C. After 30 min, the mixture was purified by reverse phase chromatography (C-18, 95% water/acetonitrile→5% water/acetonitrile with 0.1% trifluoroacetic acid) to give the title compound (41 mg). MS 517.8 (M+1).

1. customthe mixture was purified by reverse phase chromatography (C-18, 95% water/acetonitrile→5% water/acetonitrile with 0.1% trifluoroacetic acid)