Potassium Carbonate → HCID 178482267, compound

HRID 1843719Notes

Reaction equation

HRID 1843719 reaction equation
F[C:2]1[CH:3]=[CH:4][C:5]([N+:10]([O-:12])=[O:11])=[C:6]([CH:9]=1)[NH:7][CH3:8].[CH3:13][C:14]1[N:19]=[C:18]([OH:20])[CH:17]=[C:16]([OH:21])[CH:15]=1.C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[CH3:13][C:14]1[N:19]=[C:18]([OH:20])[CH:17]=[C:16]([O:21][C:2]2[CH:3]=[CH:4][C:5]([N+:10]([O-:12])=[O:11])=[C:6]([NH:7][CH3:8])[CH:9]=2)[CH:15]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 229057745-fluoro-N-methyl-2-nitroanilineHCID 178429093HCID 178429093, compound

Product 1

HCID 178482267HCID 178482267, compoundYield 89%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

The reaction and post-treatment were carried out according to Example (16c) using 5-fluoro-N-methyl-2-nitroaniline (US2003-675927, 6.30 g, 37.0 mmol), 6-methylpyridine-2,4-diol (5.09 g, 40.7 mmol), potassium carbonate (5.63 g, 40.7 mmol) and DMF (100 mL) to obtain the title compound (9.06 g, 89%) as a yellow solid.

Workup

  1. customThe reaction

Sources & evidence

ORD record
ord-08dc45ac78a04345bec8abf2f99cbcd8
Source dataset
uspto-grants-2015_02
Patent number
US08946264B2

Reaction notes

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