Sodium hydride → HCID 86661629, compound

HRID 1843724Notes

Reaction equation

HRID 1843724 reaction equation
[Cl:1][C:2]1[N:7]=[CH:6][C:5]([OH:8])=[CH:4][CH:3]=1.Cl[C:10]1[CH:11]=[CH:12][C:13]([N+:25]([O-:27])=[O:26])=[C:14]([CH2:16][NH:17][C:18](=[O:24])[O:19][C:20]([CH3:23])([CH3:22])[CH3:21])[CH:15]=1.[H-].[Na+]>CN1CCCC1=O>[Cl:1][C:2]1[N:7]=[CH:6][C:5]([O:8][C:10]2[CH:11]=[CH:12][C:13]([N+:25]([O-:27])=[O:26])=[C:14]([CH2:16][NH:17][C:18](=[O:24])[O:19][C:20]([CH3:23])([CH3:21])[CH3:22])[CH:15]=2)=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 24758Sodium hydrideHCID 8198212-Chloro-5-hydroxypyridineHCID 71357443tert-Butyl [(5-chloro-2-nitrophenyl)methyl]carbamate

Product 1

HCID 86661629HCID 86661629, compound

Reagents, catalysts & solvents 1

HCID 13387N-methyl-2-pyrrolidoneSolvent

Procedure

The reaction and post-treatment were carried out according to Example (1a) using 6-chloropyridin-3-ol (10 g, 77 mmol), tert-butyl (5-chloro-2-nitrophenyl)methylcarbamate (19 g, 66 mmol), sodium hydride (56%, 3.1 g, 77 mmol) and N-methylpyrrolidinone (80 mL) to obtain the title compound.

Workup

  1. customThe reaction

Sources & evidence

ORD record
ord-08cdb804906c44ac9755f600e63f9eb1
Source dataset
uspto-grants-2015_02
Patent number
US08946264B2

Reaction notes

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