反应详情

7-hydroxy-2-(4-methyl-pyridin-3-yl)-3,4-dihydro-2H-isoquinolin-1-one (27A: 50 mg, 0.196 mmol) was reacted with bromomethyl-cyclopropane (32 mg, 0.236 mmol) and 60% NaH (10 mg, 0.236 mmol) in DMF (2 mL) to afford the crude product. Purification by column chromatography on silica gel (15% ethylacetate in hexane) afforded 250 mg of the product (50% yield).

1. customto afford the crude product
2. customPurification by column chromatography on silica gel (15% ethylacetate in hexane)