反应详情

温度

0 °C

(4-Methoxyphenyl) methanamine (6.57 mL, 50.676 mmol) was added to a solution of 3,4-dihydro-1H-pyrano[3,4-c]pyridin-1-one (I-65c: 750 mg, 5.068 mmol) in THF (15 mL) and the resulting reaction mass was refluxed for 48 hours. The reaction was monitored by TLC (10% methanol in CHCl3). The reaction mass was cooled to 0° C., neutralized with 1N HCl and extracted using DCM. The organic layer was dried over anhydrous Na2SO4 and concentrated under reduced pressure to afford 1.5 g of the product.

1. customthe resulting reaction mass
2. temperaturewas refluxed for 48 hours
3. extractionextracted
4. dry with materialThe organic layer was dried over anhydrous Na2SO4
5. concentrationconcentrated under reduced pressure