9-Borabicyclo(3.3.1)nonane → HCID 66768828, compound

HRID 1844597Notes

Reaction equation

HRID 1844597 reaction equation
[CH:1]12[BH:9][CH:5]([CH2:6][CH2:7][CH2:8]1)[CH2:4][CH2:3][CH2:2]2.[CH2:10]=[C:11]1[CH2:16][CH2:15][N:14]([C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])[CH2:13][CH2:12]1>O1CCCC1>[CH:5]12[B:9]([CH2:10][CH:11]3[CH2:16][CH2:15][N:14]([C:17]([O:19][C:20]([CH3:21])([CH3:23])[CH3:22])=[O:18])[CH2:13][CH2:12]3)[CH:1]([CH2:8][CH2:7][CH2:6]1)[CH2:2][CH2:3][CH2:4]2

Participants

4

Reactant 2

HCID 789669-Borabicyclo(3.3.1)nonaneHCID 27568081-Boc-4-Methylenepiperidine

Product 1

HCID 66768828HCID 66768828, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

6.29 ml of a 0.5 M solution of 9-borabicyclo[3.3.1]nonane in tetrahydrofuran are added to 620 mg tert-butyl 4-methylene-piperidine-1-carboxylate under an argon atmosphere, and the reaction mixture is refluxed for 1 h. After cooling to ambient temperature the reaction solution is further reacted without any further working up.

Workup

  1. temperaturethe reaction mixture is refluxed for 1 h
  2. customis further reacted without

Sources & evidence

ORD record
ord-838f659798fa485c96891697bd5bd65c
Source dataset
uspto-grants-2015_02
Patent number
US08946438B2

Reaction notes

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