Diisopropylethylamine → (R)-4'-Methyl-N-(1-(2-methylpyrimidin-5-yl)ethyl)-5-(methylsulfonyl)biphenyl-3-carboxamide

HRID 1845222Notes

Reaction equation

[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[C:12]([S:14]([CH3:17])(=[O:16])=[O:15])[CH:11]=[C:10]([C:18]([OH:20])=O)[CH:9]=2)=[CH:4][CH:3]=1.[CH3:21][C:22]1[N:27]=[CH:26][C:25]([C@H:28]([NH2:30])[CH3:29])=[CH:24][N:23]=1.F[P-](F)(F)(F)(F)F.C[N+](C)=C(N(C)C)ON1C2N=CC=CC=2N=N1.C(N(CC)C(C)C)(C)C>CN(C)C=O.CCOC(C)=O>[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:13]=[C:12]([S:14]([CH3:17])(=[O:15])=[O:16])[CH:11]=[C:10]([C:18]([NH:30][C@@H:28]([C:25]3[CH:24]=[N:23][C:22]([CH3:21])=[N:27][CH:26]=3)[CH3:29])=[O:20])[CH:9]=2)=[CH:6][CH:7]=1

Participants

Conditions

Temperature: 25 °C

Procedure

To a solution of 4′-methyl-5-(methylsulfonyl)biphenyl-3-carboxylic acid (1.0 g, 3.44 mmol) in N,N-dimethylformamide (10 mL) were added (R)-1-(2-methylpyrimidin-5-yl)ethanamine (900 mg, 5.58 mmol), N,N,N′,N′-tetramethyl-O-(7-azabenzotriazol-1-yl)uronium hexafluorophosphate (3.0 g, 7.89 mmol) and N,N-diisopropylethylamine (3.0 mL, 17.22 mmol). The reaction mixture was stirred for 16 hours at 25° C. LC-MS indicated the reaction was complete. The reaction solution was diluted with EtOAc and washed with water, sat. aq. NaHCO3, brine and dried over anhydrous MgSO4. The residue was purified by silica gel column and preparative HPLC to afford the final product as a light color solid.

Workup

washwashed with water, sat. aq. NaHCO3, brine
dry with materialdried over anhydrous MgSO4
customThe residue was purified by silica gel column and preparative HPLC

Sources & evidence

ORD record: ord-27eb04b01128499db9eaecb93461109b
Source dataset: uspto-grants-2015_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08946439B2

Reaction notes

Loading…