反应详情

温度

60 °C

To a solution of methyl 2′-cyano-4′-methyl-5-(thiazol-2-yloxy)biphenyl-3-carboxylate (112 mg, 0.32 mmol) in tetrahydrofuran (2 mL) was added 2.5 M of aqueous lithium hydroxide solution (0.72 mL, 1.8 mmol). The reaction mixture was stirred at 60° C. overnight. The aqueous solution was acidified with 15% HCl (aq.) to pH=5, and extracted with EtOAc. The combined organic layers were concentrated in vacuo to get the title compound as a white solid.

1. extractionextracted with EtOAc
2. concentrationThe combined organic layers were concentrated in vacuo