反应详情

温度

110 °C

To a solution of 4-hydroxy-3-methylbenzaldehyde (0.50 g, 3.67 mmol) in anhydrous DMF (8 mL) was added K2CO3 (1.01 g, 7.34 mmol) and 1,3-dioxolan-2-one (0.65 g, 7.34 mmol), and the mixture was stirred at 110° C. for 60 hours under nitrogen. DMF was removed under vacuum, the residue was diluted with water (50 mL) and extracted with ethyl acetate. The organic layer was separated, washed with brine, dried over anhydrous Na2SO4 and concentrate under vacuum to give 3-methyl-4-hydroxylethoxybenzaldehyde as a yellow oil. Yield: 0.60 g (91%).

1. customDMF was removed under vacuum
2. additionthe residue was diluted with water (50 mL)
3. extractionextracted with ethyl acetate
4. customThe organic layer was separated
5. washwashed with brine
6. dry with materialdried over anhydrous Na2SO4
7. concentrationconcentrate under vacuum