Water → HCID 86663909, compound

HRID 1846458Notes

Reaction equation

HRID 1846458 reaction equation
[H-].[Na+].O[C:4]1([CH3:14])[CH:13]=[CH:12][C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[NH:5]1.[Cl:15][C:16]1[CH:21]=[C:20](Cl)[N:19]=[CH:18][N:17]=1.[OH2:23]>CN(C=O)C>[Cl:15][C:16]1[N:17]=[CH:18][N:19]=[C:20]([O:23][C:12]2[C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[N:5]=[C:4]([CH3:14])[CH:13]=2)[CH:21]=1

Participants

6

Reactant 4

HCID 962WaterHCID 24758Sodium hydrideHCID 709434,6-DichloropyrimidineHCID 669782272-Methyl-1,2-dihydroquinolin-2-ol

Product 1

HCID 86663909HCID 86663909, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

36 mg (0.83 mmol) sodium hydride (55%, suspension in mineral oil) were added to 0 10 g (0.68 mmol) 2-hydroxy-2-methylquinoline in 1.5 mL DMF and the mixture was stirred for 15 min. Then 97 mg (0.63 mmol) 4,6-dichloropyrimidine were added and the mixture was stirred overnight at RT. The reaction mixture was mixed with water and left to stand overnight. The precipitate formed was suction filtered, washed with water and dried i. vac.

Workup

  1. stirringthe mixture was stirred overnight at RT
  2. waitleft
  3. waitto stand overnight
  4. customThe precipitate formed
  5. filtrationfiltered
  6. washwashed with water
  7. customdried i

Sources & evidence

ORD record
ord-9d97ed535dc648baa4b90fba628aebf0
Source dataset
uspto-grants-2015_02
Patent number
US08952014B2

Reaction notes

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