反应详情

0.12 g (0.97 mmol) 2,6-dimethyl-4-hydroxypyridine and 55 mg (1.26 mmol) sodium hydride (60% dispersion in mineral oil) were dissolved in 1.5 mL DMF and stirred for 15 min. 0.15 g (0.98 mmol) 4,6-dichloropyrimidine were added and the mixture was stirred overnight at RT. The reaction mixture was acidified with a 4M hydrochloric acid, filtered and purified by preparative HPLC-MS. The fractions containing product were combined and freeze-dried.

1. stirringthe mixture was stirred overnight at RT
2. filtrationfiltered
3. custompurified by preparative HPLC-MS
4. additionThe fractions containing product
5. customfreeze-dried