Potassium Carbonate → HCID 86663918, compound

HRID 1846479Notes

Reaction equation

HRID 1846479 reaction equation
[CH3:1][C:2]1[C:10]2[N:9]=[C:8]([C@@H:11]3[CH2:15][CH2:14][CH2:13][O:12]3)[NH:7][C:6]=2[CH:5]=[C:4]([OH:16])[CH:3]=1.[Cl:17][C:18]1[CH:23]=[C:22](Cl)[N:21]=[CH:20][N:19]=1.C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[Cl:17][C:18]1[N:19]=[CH:20][N:21]=[C:22]([O:16][C:4]2[CH:3]=[C:2]([CH3:1])[C:10]3[N:9]=[C:8]([C@@H:11]4[CH2:15][CH2:14][CH2:13][O:12]4)[NH:7][C:6]=3[CH:5]=2)[CH:23]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 709434,6-DichloropyrimidineHCID 66978269HCID 66978269, compound

Product 1

HCID 86663918HCID 86663918, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
50 °C

Procedure

135 mg (0.62 mmol) (S)-4-methyl-2-(tetrahydrofuran-2-yl)-1H-benzo[d]imidazol-6-ol and 97 mg (0.63 mmol) 4,6-dichloropyrimidine in 2.0 mL DMF were combined with 97 mg (0.70 mmol) potassium carbonate and stirred overnight at 50° C. Then ice water was added and the mixture was extracted with ethyl acetate. The organic phase was concentrated by rotary evaporation i.vac.

Workup

  1. extractionthe mixture was extracted with ethyl acetate
  2. concentrationThe organic phase was concentrated by rotary evaporation i.vac

Sources & evidence

ORD record
ord-d1b6d4742ccc441d87206dc3be861d8b
Source dataset
uspto-grants-2015_02
Patent number
US08952014B2

Reaction notes

Loading…