Water → HCID 86663919, compound

HRID 1846483Notes

Reaction equation

HRID 1846483 reaction equation
Cl[C:2]1[CH:7]=[C:6]([Cl:8])[N:5]=[CH:4][N:3]=1.[Cl:9][C:10]1[C:18]2[N:17]=[C:16]([CH3:19])[NH:15][C:14]=2[CH:13]=[CH:12][C:11]=1[OH:20].C(=O)([O-])[O-].[K+].[K+].O>CN(C=O)C>[Cl:9][C:10]1[C:18]2[N:17]=[C:16]([CH3:19])[NH:15][C:14]=2[CH:13]=[CH:12][C:11]=1[O:20][C:2]1[CH:7]=[C:6]([Cl:8])[N:5]=[CH:4][N:3]=1

Participants

6

Reactant 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 709434,6-DichloropyrimidineHCID 14365009HCID 14365009, compound

Product 1

HCID 86663919HCID 86663919, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

270 mg (1.81 mmol) 4,6-dichloropyrimidine, 330 mg (1.81 mmol) 4-chloro-5-hydroxy-2-methyl-1H-benzo[d]imidazole and 270 mg (1.95 mmol) potassium carbonate in 1.5 mL DMF were stirred for 2 h at RT. The reaction mixture was mixed with water and the precipitate formed was suction filtered, washed and dried.

Workup

  1. customthe precipitate formed
  2. filtrationfiltered
  3. washwashed
  4. customdried

Sources & evidence

ORD record
ord-b550eef10a354aa9ad7a9d11ed0adb89
Source dataset
uspto-grants-2015_02
Patent number
US08952014B2

Reaction notes

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