Hydrochloric Acid → HCID 21820480, compound

HRID 1846484Notes

Reaction equation

HRID 1846484 reaction equation
[CH3:1][C:2]1[C:3]([N+:16]([O-:18])=[O:17])=[C:4](CC([O-])=O)[CH:5]=[C:6](CC([O-])=O)[CH:7]=1.[OH-:19].[Li+].Cl.C[OH:23]>>[CH3:1][C:2]1[C:3]([N+:16]([O-:18])=[O:17])=[C:4]([OH:23])[CH:5]=[C:6]([OH:19])[CH:7]=1

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 3939Lithium HydroxideHCID 86663920HCID 86663920, compound

Product 1

HCID 21820480HCID 21820480, compound

Procedure

A mixture of 1.15 g (3.63 mmol) 5-methyl-4-nitro-1,3-phenylenediacetate and 10.0 mL (10.0 mmol) 1M aqueous lithium hydroxide solution in 10.0 mL methanol was stirred overnight at RT. The reaction mixture was acidified with 4M hydrochloric acid and extracted with dichloromethane. The organic phase was separated off, dried and evaporated down i.vac. The residue was purified by chromatography. The fractions containing product were combined and evaporated down i.vac.

Workup

  1. extractionextracted with dichloromethane
  2. customThe organic phase was separated off
  3. customdried
  4. customevaporated down i.vac
  5. customThe residue was purified by chromatography
  6. additionThe fractions containing product
  7. customevaporated down i.vac

Sources & evidence

ORD record
ord-0411a80bd0d04be99aa34b5cb1dd53e2
Source dataset
uspto-grants-2015_02
Patent number
US08952014B2

Reaction notes

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