Water → HCID 86663921, compound

HRID 1846487Notes

Reaction equation

HRID 1846487 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]([CH3:13])[C:5]2[NH:10][C:9](=[O:11])[CH2:8][O:7][C:6]=2[CH:12]=1.C(=O)([O-])[O-].[K+].[K+].[Cl:20][C:21]1[CH:26]=[C:25](Cl)[N:24]=[CH:23][N:22]=1.O>CN(C=O)C>[Cl:20][C:21]1[N:22]=[CH:23][N:24]=[C:25]([O:1][C:2]2[CH:3]=[C:4]([CH3:13])[C:5]3[NH:10][C:9](=[O:11])[CH2:8][O:7][C:6]=3[CH:12]=2)[CH:26]=1

Participants

6

Reactant 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 709434,6-DichloropyrimidineHCID 669780401231750-12-1

Product 1

HCID 86663921HCID 86663921, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

0.10 g (0.56 mmol) 7-hydroxy-5-methyl-2H-benzo[b][1.4]oxazin-3(4H)-one and 0.10 g (0.73 mmol) potassium carbonate were placed in 2.0 mL DMF. After 15 min 86 mg (0.56 mmol) 4,6-dichloropyrimidine were added andtmw stirred at RT over the weekend. The reaction mixture was mixed with water, the substance was extracted with ethyl acetate and evaporated down i.vac.

Workup

  1. extractionthe substance was extracted with ethyl acetate
  2. customevaporated down i.vac

Sources & evidence

ORD record
ord-bbbb97480858481b8d8c1c11f8176123
Source dataset
uspto-grants-2015_02
Patent number
US08952014B2

Reaction notes

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