Potassium Carbonate → HCID 178478257, compound

HRID 1846493Notes

Reaction equation

HRID 1846493 reaction equation
[Cl:1][C:2]1[C:7]2[NH:8][C:9]([CH:11]3[CH2:15][CH2:14][O:13][CH2:12]3)=[N:10][C:6]=2[CH:5]=[C:4]([OH:16])[CH:3]=1.[Cl:17][C:18]1[CH:23]=[C:22](Cl)[N:21]=[CH:20][N:19]=1.C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[Cl:1][C:2]1[C:7]2[NH:8][C:9]([CH:11]3[CH2:15][CH2:14][O:13][CH2:12]3)=[N:10][C:6]=2[CH:5]=[C:4]([O:16][C:22]2[CH:23]=[C:18]([Cl:17])[N:19]=[CH:20][N:21]=2)[CH:3]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 709434,6-DichloropyrimidineHCID 178516181HCID 178516181, compound

Product 1

HCID 178478257HCID 178478257, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

80 mg (0.34 mmol) 7-chloro-2-(tetrahydrofuran-3-yl)-1H-benzo[d]imidazol-5-ol and 51 mg (0.34 mmol) 4,6-dichloropyrimidine were placed in 2.0 mL DMF. 55 mg (0.40 mmol) potassium carbonate were added and the mixture was stirred overnight at RT. The reaction mixture was filtered and purified by chromatography. The fractions containing product were combined and evaporated down i.vac.

Workup

  1. filtrationThe reaction mixture was filtered
  2. custompurified by chromatography
  3. additionThe fractions containing product
  4. customevaporated down i.vac

Sources & evidence

ORD record
ord-9ee0f92b5f7a4a21abe5f6306fc8485c
Source dataset
uspto-grants-2015_02
Patent number
US08952014B2

Reaction notes

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