Potassium Carbonate → HCID 178478258, compound

HRID 1846497Notes

Reaction equation

HRID 1846497 reaction equation
[Cl:1][C:2]1[C:7]2[NH:8][C:9]([CH:11]3[CH2:16][CH2:15][O:14][CH2:13][CH2:12]3)=[N:10][C:6]=2[CH:5]=[C:4]([OH:17])[CH:3]=1.[Cl:18][C:19]1[CH:24]=[C:23](Cl)[N:22]=[CH:21][N:20]=1.C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[Cl:1][C:2]1[C:7]2[NH:8][C:9]([CH:11]3[CH2:12][CH2:13][O:14][CH2:15][CH2:16]3)=[N:10][C:6]=2[CH:5]=[C:4]([O:17][C:23]2[CH:24]=[C:19]([Cl:18])[N:20]=[CH:21][N:22]=2)[CH:3]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 709434,6-DichloropyrimidineHCID 178516182HCID 178516182, compound

Product 1

HCID 178478258HCID 178478258, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

0.10 g (0.40 mmol) 7-chloro-2-(tetrahydro-2H-pyran-4-yl)-1H-benzo[d]imidazol-5-ol and 60 mg (0.40 mmol) 4,6-dichloropyrimidine were placed in 2.0 mL DMF. 61 mg (0.40 mmol) potassium carbonate were added and the mixture was stirred overnight at RT. The reaction mixture was filtered and purified by chromatography. The fractions containing product were combined and evaporated down i.vac.

Workup

  1. filtrationThe reaction mixture was filtered
  2. custompurified by chromatography
  3. additionThe fractions containing product
  4. customevaporated down i.vac

Sources & evidence

ORD record
ord-b7b1107088c24a0eb6095b61c07fe312
Source dataset
uspto-grants-2015_02
Patent number
US08952014B2

Reaction notes

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