Water → HCID 86663925, compound

HRID 1846501Notes

Reaction equation

HRID 1846501 reaction equation
[OH:1][C:2]1[CH:11]=[C:10]([CH3:12])[C:5]2[NH:6][C:7](=[O:9])[S:8][C:4]=2[CH:3]=1.[Cl:13][C:14]1[CH:19]=[C:18](Cl)[N:17]=[CH:16][N:15]=1.C(=O)([O-])[O-].[K+].[K+].O>CN(C=O)C>[Cl:13][C:14]1[N:15]=[CH:16][N:17]=[C:18]([O:1][C:2]2[CH:11]=[C:10]([CH3:12])[C:5]3[NH:6][C:7](=[O:9])[S:8][C:4]=3[CH:3]=2)[CH:19]=1

Participants

6

Reactant 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 709434,6-DichloropyrimidineHCID 669782906-Hydroxy-4-methyl-2(3H)-benzothiazolone

Product 1

HCID 86663925HCID 86663925, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

0.30 g (1.66 mmol) 6-hydroxy-4-methylbenzo[d]thiazol-2(3H)-one and 0.25 g (1.68 mmol) 4,6-dichloropyrimidine were placed in 2.0 mL DMF. 0.25 g (1.81 mmol) potassium carbonate were added and the mixture was stirred for 2 h at RT. The reaction mixture was mixed with water and stirred overnight. The precipitate formed was suction filtered, washed and dried.

Workup

  1. stirringstirred overnight
  2. customThe precipitate formed
  3. filtrationfiltered
  4. washwashed
  5. customdried

Sources & evidence

ORD record
ord-0fcd3a531c454f04a074d42754ddef23
Source dataset
uspto-grants-2015_02
Patent number
US08952014B2

Reaction notes

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