Potassium Carbonate → HCID 86663927, compound

HRID 1846508Notes

Reaction equation

HRID 1846508 reaction equation
[CH3:1][O:2][C:3]1[NH:7][C:6]2[CH:8]=[C:9]([OH:13])[CH:10]=[C:11]([CH3:12])[C:5]=2[N:4]=1.[Cl:14][C:15]1[CH:20]=[C:19](Cl)[N:18]=[CH:17][N:16]=1.C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[Cl:14][C:15]1[N:16]=[CH:17][N:18]=[C:19]([O:13][C:9]2[CH:10]=[C:11]([CH3:12])[C:5]3[N:4]=[C:3]([O:2][CH3:1])[NH:7][C:6]=3[CH:8]=2)[CH:20]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 709434,6-DichloropyrimidineHCID 66978274HCID 66978274, compound

Product 1

HCID 86663927HCID 86663927, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
50 °C

Procedure

74 mg (0.42 mmol) 2-methoxy-4-methyl-1H-benzo[d]imidazol-6-ol and 68 mg (0.44 mmol) 4,6-dichloropyrimidine were placed in 2.0 mL DMF. 0.12 g (0.88 mmol) potassium carbonate were added and the mixture was stirred for 4 h at 50° C. The reaction mixture was combined with ice water, the substance was extracted with ethyl acetate and evaporated down i.vac.

Workup

  1. extractionthe substance was extracted with ethyl acetate
  2. customevaporated down i.vac

Sources & evidence

ORD record
ord-f2bc204380f941459aef11ccbe596556
Source dataset
uspto-grants-2015_02
Patent number
US08952014B2

Reaction notes

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