Potassium Carbonate → HCID 46244317, compound

HRID 1846529Notes

Reaction equation

HRID 1846529 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]2[NH:12][C:11](=[O:13])[N:10]([CH:14]3[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]3)[CH2:9][CH2:8][C:7]=2[CH:20]=1.Cl[C:22]1[N:27]=[CH:26][N:25]=[C:24]([N:28]([C:32]2[CH:42]=[C:41]([CH3:43])[C:35]3[N:36]([CH3:40])[C:37](=[O:39])[O:38][C:34]=3[CH:33]=2)[C:29](=[O:31])[CH3:30])[CH:23]=1.C(=O)([O-])[O-].[K+].[K+]>CN1C(=O)CCC1>[CH3:40][N:36]1[C:35]2[C:41]([CH3:43])=[CH:42][C:32]([N:28]([C:24]3[CH:23]=[C:22]([N:17]4[CH2:18][CH2:19][CH:14]([N:10]5[CH2:9][CH2:8][C:7]6[CH:20]=[C:3]([O:2][CH3:1])[CH:4]=[CH:5][C:6]=6[NH:12][C:11]5=[O:13])[CH2:15][CH2:16]4)[N:27]=[CH:26][N:25]=3)[C:29](=[O:31])[CH3:30])=[CH:33][C:34]=2[O:38][C:37]1=[O:39]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 183568527-methoxy-3-(piperidin-4-yl)-4,5-dihydro-1H-benzo[d][1,3]diazepin-2(3H)-oneHCID 86663901HCID 86663901, compound

Product 1

HCID 46244317HCID 46244317, compound

Reagents, catalysts & solvents 1

HCID 13387N-methyl-2-pyrrolidoneSolvent

Conditions

Temperature
80 °C

Procedure

59 mg (0.21 mmol) 7-methoxy-3-piperidin-4-yl-1,3,4,5-tetrahydro-1,3-benzodiazepin-2-one, 65 mg (0.19 mmol) N-(6-chloro-pyrimidin-4-yl)-N-(3,4-dimethyl-2-oxo-2,3-dihydro-benzoxazol-6-yl)-acetamide and 81 mg (0.59 mmol) potassium carbonate in 1.5 mL NMP were combined and stirred at 80° C. The reaction mixture was purified by preparative HPLC. The product-containing fractions were combined and evaporated down. The solid obtained was washed with diethyl ether and dried.

Workup

  1. customThe reaction mixture was purified by preparative HPLC
  2. customevaporated down
  3. customThe solid obtained
  4. washwas washed with diethyl ether
  5. customdried

Sources & evidence

ORD record
ord-d96357fa18f04c459a45823163da28f5
Source dataset
uspto-grants-2015_02
Patent number
US08952014B2

Reaction notes

Loading…