Diisopropylethylamine → Lapatinib

HRID 1847201Notes

Reaction equation

HRID 1847201 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([NH:17][C:18]2[C:27]3[C:22](=[CH:23][CH:24]=[C:25]([C:28]4[O:32][C:31]([CH:33]=O)=[CH:30][CH:29]=4)[CH:26]=3)[N:21]=[CH:20][N:19]=2)[CH:5]=[CH:6][C:7]=1[O:8][CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[C:12]([F:16])[CH:11]=1.Cl.[NH2:36][CH2:37][CH2:38][S:39]([CH3:42])(=[O:41])=[O:40].C(N(CC)C(C)C)(C)C.O.[C:53]1([CH3:63])[CH:58]=[CH:57][C:56]([S:59]([OH:62])(=[O:61])=[O:60])=[CH:55][CH:54]=1>CO.ClCCl.[Pt]>[CH3:63][C:53]1[CH:54]=[CH:55][C:56]([S:59]([O-:62])(=[O:61])=[O:60])=[CH:57][CH:58]=1.[CH3:42][S:39]([CH2:38][CH2:37][NH:36][CH2:33][C:31]1[O:32][C:28]([C:25]2[CH:24]=[CH:23][C:22]3[N:21]=[CH:20][N:19]=[C:18]([NH:17][C:4]4[CH:5]=[CH:6][C:7]([O:8][CH2:9][C:10]5[CH:15]=[CH:14][CH:13]=[C:12]([F:16])[CH:11]=5)=[C:2]([Cl:1])[CH:3]=4)[C:27]=3[CH:26]=2)=[CH:29][CH:30]=1)(=[O:41])=[O:40]

Participants

9

Reactant 4

HCID 81531DiisopropylethylamineHCID 521998p-Toluenesulfonic acid monohydrateHCID 11181296(5-(4-(4-((3-Fluorobenzyl)oxy)-3-chloroanilino)-6-quinazolinyl)-2-furancarboxaldehydeHCID 17749886Ethanamine, 2-(methylsulfonyl)-, hydrochloride (1:1)

Product 2

HCID 85570p-ToluenesulfonateHCID 208908LapatinibYield 81.8%

Reagents, catalysts & solvents 3

HCID 23939PlatinumCatalystHCID 887MethanolSolvent3×HCID 6344DichloromethaneSolvent2×

Procedure

The suspension of 5-[4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)quinazolin-6-yl]-2-furaldehyde (5 g, 10.6 mmoL) and 2-aminoethylmethylsulfone hydrochloride (3 g, 19 mmoL) in methanol (10 mL) and dichloromethane (25 mL) was charged with N,N-diisopropylethylamine (1.6 g, 12.7 mmoL) slowly under constant stirring at room temperature. The reaction mixture was stirred for 2-4 hours until reaction completion. The reaction mixture was charged with 10% Pt—C (500 mg) and stirred under hydrogen atmosphere (after evacuation) for 16-24 hours until reaction completion. The reaction mixture was further charged with methanol (25 mL) and dichloromethane (25 mL) and stirred for 12-16 hours. The obtained mixture was filtered, washed with 1:1 mixture of methanol (20 mL) and dichloromethane (20 mL). The yellow filtrate thus obtained was slowly charged with a solution of p-toluenesulfonic acid monohydrate (2 g, 10.6 mmoL) in methanol (5 mL). The yellow solid which precipitated out was filtered and washed with 1:1 mixture of methanol (20 mL) and dichloromethane (20 mL). The solid obtained was dried under vacuum at 40-45° C. to afford the monotosylate salt of Lapatinib (5 g, Yield=61%, HPLC purity>99%).

Workup

  1. stirringThe reaction mixture was stirred for 2-4 hours until reaction completion
  2. stirringstirred under hydrogen atmosphere (after evacuation) for 16-24 hours
  3. customuntil reaction completion
  4. stirringstirred for 12-16 hours
  5. filtrationThe obtained mixture was filtered
  6. washwashed with 1:1 mixture of methanol (20 mL) and dichloromethane (20 mL)
  7. customThe yellow filtrate thus obtained
  8. customThe yellow solid which precipitated out
  9. filtrationwas filtered
  10. washwashed with 1:1 mixture of methanol (20 mL) and dichloromethane (20 mL)
  11. customThe solid obtained
  12. customwas dried under vacuum at 40-45° C.

Sources & evidence

ORD record
ord-b6eb92fee91142a283908b32a5992eae
Source dataset
uspto-grants-2015_02
Patent number
US08952154B2

Reaction notes

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