Dichloromethane → HCID 68613712, compound

HRID 1848281Notes

Reaction equation

HRID 1848281 reaction equation
Cl[CH2:2][Cl:3].C(Cl)(=O)C(Cl)=O.[C:10]([C:13]1[CH:21]=[CH:20][C:16](C(O)=O)=[C:15]([CH3:22])[CH:14]=1)(=[O:12])[CH3:11]>CN(C)C=O>[C:10]([C:13]1[CH:21]=[CH:20][C:16]([CH2:2][Cl:3])=[C:15]([CH3:22])[CH:14]=1)(=[O:12])[CH3:11]

Participants

5

Reactant 3

HCID 6344DichloromethaneHCID 65578Oxalyl chlorideHCID 534355544-Acetyl-2-methylbenzoic acid

Product 1

HCID 68613712HCID 68613712, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

28 ml of dichloromethane, 4 ml of oxalyl chloride, and a drop of N,N-dimethylformamide were added to 5.0 g of 4-acetyl-2-methylbenzoic acid, and the mixture was stirred for 3 hours at room temperature. After removing the solvent by distilling under reduced pressure, 5.6 g of crude 4-acetyl-2-methylbenzyl chloride was obtained.

Workup

  1. customAfter removing the solvent
  2. distillationby distilling under reduced pressure

Sources & evidence

ORD record
ord-7cc8f63a881b46209ee2126ddfb3cc6d
Source dataset
uspto-grants-2015_02
Patent number
US08952175B2

Reaction notes

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