反应详情

温度

100 °C

500 mg of 4-hydroxybenzamide, 1.51 g of potassium carbonate, 10 mL of DMF and 730 mg of 3-chloro-1,1-diethoxypropane are added to a flask. The reaction mixture is stirred at 100° C. for 18 hours and then 5 mL of water are added. The aqueous phase is extracted with ethyl acetate, and then the organic phases are collected, washed with water and concentrated under reduced pressure. The product is obtained in the form of a powder in a yield of 89% and with a chemical purity of 95%.

1. extractionThe aqueous phase is extracted with ethyl acetate
2. customthe organic phases are collected
3. washwashed with water
4. concentrationconcentrated under reduced pressure
5. customThe product is obtained in the form of a powder in a yield of 89% and with a chemical purity of 95%